Chris Lumb
Research Assistant
Rm 432, Bio21 Institute
University of Melbourne
Phone: +61 3 8344 2504
Fax: +61 3 9347 5352
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My work focuses on the role of cytochrome p450s in insect development and their possible involvement in insecticide resistance. P450s are a large gene family capable of catalysing many different chemical reactions. Much of our previous work has focussed on the roles these genes may play in insecticide resistance, however for many of these genes, little is known about their native roles.

Through transgenic over-expression and knock-down of these genes, as well as examination of expression patterns, I hope to determine what some of these native functions may be.

Daborn PJ, Lumb C, Boey A, Wong W, Ffrench-Constant RH, Batterham P. Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression.I nsect Biochem Mol Biol. 2007 May;37(5):512-9

Willoughby L, Chung H, Lumb C, Robin C, Batterham P, Daborn PJ. A comparison of Drosophila melanogaster detoxification gene induction responses for six insecticides, caffeine and phenobarbital.  Insect Biochem Mol Biol. 2006 Dec;36(12):934-42.

Chen Z, Robin C, Damiano J, Lydall J, Lumb C, Smith K, Blasetti A, Daborn PJ, Heckel D, McKenzie JA, Batterham P. Positional cloning of a cyromazine resistance gene in Drosophila melanogaster.  Insect Mol Biol. 2006 Apr;15(2):181-6.