Dr Philip Daborn
405, Bio21 Institute
University of Melbourne
Phone: +61 3 8344 2362
Fax: +61 3 9347 5352
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Phillip Daborn completed his undergraduate studies at The University of Melbourne where he obtained a B.Sc(Hons) degree in 1994. In 1999 he then completed a Ph.D. in Genetics at The University of Melbourne, under the guidance of Assoc. Prof. Philip Batterham and Prof. John McKenzie. After a four-year postdoctoral position at the University of Bath, UK, with Prof. Richard ffrench-Constant, working on projects including characterising the molecular basis of insecticide resistance Drosophila melanogaster and the identification of insecticidal toxins produced by the insect-killing bacterium Photorhabdus luminescens, Phillip returned to The University of Melbourne in Nov 2003 to take up an Australian Research Council Fellowship based within CESAR and in 2007 was awarded an ARC ARF Fellowship

Current Research

Publications

A. Hoffmann and P. J. Daborn (2007). Towards genetic markers in animal populations as biomonitors for human-induced environmental change. Ecology Letters 9:1-14.

Charles Robin, Phillip J. Daborn and Ary A. Hoffmann (2007). Fighting Fly Genes. Trends in Genetics 23:51-54. 

H. Chung, M. R. Bogwitz, C. McCart, A. Andrianopoulos, R. H. ffrench-Constant, P. Batterham and P. J. Daborn (2007). Tissue Specific Enhancers in the Accord Retrotransposon Result in Insecticide Resistance in Drosophila melanogaster. Genetics 175:1071-1077.

Phillip J. Daborn, Christopher Lumb, Adrian Boey, Wayn Wong, Richard H. ffrench-Constant and Philip Batterham. (2007). Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression. Insect Biochemistry and Molecular Biology 37:512-519. 

L. Willoughby, P. Batterham and P. J. Daborn. (2007). Piperonyl butoxide induces the expression of cytochrome P450 and glutathione S-transferase genes in Drosophila melanogaster. Pest Management Science 63:803-808.

Tamar Sztal, Henry Chung, Lydia Gramzow, Phillip J. Daborn, Philip Batterham and Charles Robin. (2007).  Two independent duplications forming the Cyp307a genes in Drosophila. Insect Biochemistry and Molecular Biology  37:1044-1053.

Z. Chen, C. Robin, J. Damiano, C. Lumb, J. Lydall, P. J. Daborn, D. Heckel, J. A. McKenzie and P. Batterham (2006). Positional cloning of a cyromazine resistance gene in Drosophila melanogaster. Insect Molecular Biology 15:181-186.

R. H. ffrench-Constant, R. Feyereisen and P. J. Daborn (2006). Resistance and the jumping gene. Bioessays 28:6-8.

A. Van de Wouw, P. Batterham and P. J. Daborn (2006). The insect growth regulator insecticide cyromazine causes earlier emergence in Drosophila melanogaster. Archives of Insect Biochemistry and Physiology 63:101-109

L. Willoughby, H. Chung, C. Lumb, C. Robin, P. Batterham and P. J. Daborn. (2006). Insecticides do not induce the transcription of genes involved in their metabolism. Insect Biochemistry and Molecular Biology36:934-942

R. H. ffrench-Constant, N. Waterfield and P. J. Daborn. (2005). Insecticidal toxins from Photorhabdus and Xenorhabdus. In Comprehensive Insect Science. A Revision of Comprehensive Insect Physiology, Biochemistry, Pharmacology and Molecular Biology. Editors: L. I. Gilbert, K. Iatrou and S. Gill. Elsevier Science, UK.

L. Magoc, J. L. Yen, A. Hill-Williams, J. A. McKenzie, P. Batterham and P. J. Daborn. (2005). Cross-resistance to dicyclanil in cyromazine-resistant mutants of Drosophila melanogaster and Lucilia cuprina Pesticide Biochemistry and Physiology 81:129-135.

M. R. Bogwitz, H. Chung, L. Magoc, S. Rigby, W. Wong, M. O'Keefe, P. Batterham and P. J. Daborn. (2005). Cyp12a4 confers lufenuron resistance in a natural population of Drosophila melanogaster. Proceedings of the National Academy of Sciences, USA 102:12807-12812

R. H. ffrench-Constant, P. J. Daborn and G. Le Goff. (2004). The genetics and genomics of insecticide resistance. Trends in Genetics 20:163-170.

A.J. Dowling, P. J. Daborn, N. R. Waterfield, P. Wang, C. H. Streuli and R. H. ffrench-Constant. (2004). The insecticidal toxin Makes caterpillars floppy (Mcf) promotes apoptosis in mammalian cells. Cellular Microbiology 6:345-353.

P. J. Daborn, C. McCart, D. Woods and R. H. ffrench-Constant. (2004). Detection of insecticide resistance-associated mutations in cat flea Rdl by TaqMan-allele specific amplification. Pesticide Biochemistry and Physiology 79:25-30.

F. Catania, M. Kauer, P. J. Daborn, J. L. Yen, R. H. ffrench-Constant and C. Schlotterer¶. (2004). Microsatellite mapping in Drosophila melanogaster shows a selective sweep around the insecticide resistance gene Cyp6g1. Molecular Ecology 13:2491-2504.

N. R. Waterfield, P.J. Daborn and R.H. ffrench-Constant. (2004). Insect pathogenicity islands in the insect pathogenic bacterium Photorhabdus. Physiological Entomolology 29:240-250.

R. H. ffrench-Constant, N. R. Waterfield, P. J. Daborn, S. Joyce, H. Bennett, C. Au, A. Dowling, S. Boundy, S. Reynolds and D. Clarke. (2003). Photorhabdus: towards a functional genomics of a symbiont and pathogen. FEMS Microbiology Reviews 26:433-456.

G. Le Goff, S. Boundy, P. J. Daborn, J. L. Yen, L. Sofer, R. Lind, C. Sabourault, L. Madi-Ravazzi and R. H. ffrench-Constant. (2003). Microarray analysis of cytochrome P450 mediated insecticide resistance in Drosophila. Insect Biochemistry and Molecular Biology 33:701-708.

N. R. Waterfield, P. J. Daborn, A. J. Dowling, G. Yang, M. Hares, and R. H. ffrench-Constant. (2003). The insecticidal toxin Makes caterpillars floppy 2 (Mcf2) shows similarity to HrmA, an avirulence protein from a plant pathogen. FEMS Microbiology Letters 229:264-270

P. J. Daborn, J.L. Yen, M. Bogwitz G. LeGoff, E. Feil, S. Jeffers, N. Tijet, T. Perry, D. Heckel, P. Batterham, R. Feyereisen, T. Wilson and R. H. ffrench-Constant. (2002). A single allele of a P450 gene is associated with insecticide resistance in Drosophila. Science 297:2353-2356

P. J. Daborn, N. Waterfield, C. P. Silva, C.P.Y. Au, S. Sharma and R. H. ffrench-Constant. (2002). A single Photorhabdus gene makes caterpillars floppy allows Escherichia coli to persist within and kill insects. Proceedings of the National Academy of Sciences, USA 99:10742-10747.

N. R. Waterfield, P. J. Daborn and R.H. ffrench-Constant. (2002). Pathogenicity islands in the insect pathogen Photorhabdus. Trends in Microbiology 10:541-545

C. P. Silva, N. R. Waterfield, P. J. Daborn, C.P.Y. Au, S. Sharma, U. Potter, P. Dean, T. Chilver, S.E. Reynolds and R. H. ffrench-Constant. (2002). Insect models of bacterial infection: infection of Manduca sexta by Photorhabdus luminescens. Cellular Microbiology 4:329-340

P. Daborn, S. Boundy, J. Yen, B. Pittendrigh and R. ffrench-Constant. (2001). DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. Molecular Genetics and Genomics 266:556-563.

P.J. Daborn, N. Waterfield, M. A. Blight and R.H. ffrench-Constant. (2001). Measuring virulence factor expression by the pathogenic bacterium Photorhabdus luminescens in culture and during insect infection. Journal of Bacteriology 183:5834-9.

N. Waterfield, A. Dowling, S. Sharma, P.J. Daborn, U. Potter and R. H. ffrench-Constant. (2001). Oral Toxicity of Photorhabdus luminescens W14 Toxin Complexes in Escherichia coli. Applied and Environmental Microbiology 67:5017-24.

P. J. Daborn, J. A. McKenzie and P. Batterham. (2000). A genetic analysis of cyromazine resistance in Drosophila melanogaster (Diptera: Drosophilidae). Journal of Economic Entomology 93:911-919.

R. H. ffrench-Constant, N. Waterfield, V. Burland, N. T. Perna, P. J. Daborn, D. Bowen and F. R.Blattner. (2000). A Genomic Sample Sequence of the Entomopathogenic Bacterium Photorhabdus luminescens W14: Potential Implications for Virulence. Applied and Environmental Microbiology 66:3310-3329.