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Project summary
Waddington
(1942) defined the term “canalization” as a measure of the ability of a
genotype to produce the same phenotype regardless of variability of its
environment. Molecular chaperons such as
heat shock proteins (HSPs) are considered to be one of the molecular
machineries of the canalization. Rutherford
and Lindquist (1998) showed developmental abnormalities associated with
deficits of Hsp90, one of the most abundantly expressed HSPs in eukaryotic
cells, and suggested the role of Hsp90 as an evolutionary capacitor. Since then, the effect of Hsp90 on
developmental stability has been well studied in D. melanogaster. However, there are also several other Hsps that
increase their expression under environmental stresses. Each Hsp may have specific response to environmental
stresses, and epistatic interactions between Hsps may play an important role in
developmental buffering. In the current
project, my objectives are 1) to reveal environmental stress specific
canalization mechanism, and 2) to examine the combined effect of Hsps on developmental
buffering.
Education
2001 BS, The University of Tokyo
2003 MS, Graduate
School of Agricultural and Life
Sciences, The University
of Tokyo
2006 Ph.D, Graduate
School of Environmental Earth Science,
Hokkaido University
Research and Professional Experience
2003.04.01~2006.03.31
Research Fellow of the Japan
Society of Promotion for Sciences (DC1)
2006.04.01~2007.03.31
Project Researcher at National Institute of Genetics
2007.04.01~2010.03.31
Postdoctoral Research Fellow of the Japan Society of Promotion for
Sciences (PD)
Publications
Kazuo
H. Takahashi, Kentaro Tanaka, Masanobu Itoh, Toshiyuki Takano-Shimizu. Selection acting on X chromosome in a natural
population of Drosophila melanogaster. submitted to Journal of Heredity.
Kazuo
H. Takahashi. 2007. The effect of travel on oviposition behavior and spatial
egg aggregation: experiments with Drosophila. Entomologia Experimentalis et
Applicata 124: 241-248.
Kazuo
H. Takahashi. 2007. Biases in the estimation of spatial egg aggregation and
association based on emergence data. Ecological Research 22: 459-466.
Nobuko
Tuno, Kazuo H. Takahashi, Hiroshi Yamashita, Naoya Osawa, Chihiro Tanaka. 2007.
Tolerance of Drosophila flies to ibotenic acid poisons in mushrooms. Journal of
Chemical Ecology 33: 311-317.
Hideyuki
Mitsui, Kazuo H. Takahashi and Masahito T. Kimura. 2006. Spatial distributions
and clutch sizes of Drosophila species ovipositing
on cherry fruits of different stages. Population Ecology 48: 233-237.
Kazuo
H. Takahashi. 2006. Spatial aggregation and association in different
resource-patch distributions: Experimental analysis with Drosophila.
Journal of Animal Ecology 75: 266-273.
Kazuo
H. Takahashi, and Masahito T. Kimura. 2005. Intraspecific and interspecific
larval interaction in Drosophila assessed by integrated fitness measure. OIKOS 111:
574-581.
Kazuo
H. Takahashi and Takashi Kagaya. 2005. Guild structure of wood-rotting fungi
based on volume and decay stage of coarse woody debris. Ecological Research 20:
215-222.
Kazuo
H. Takahashi, Nobuko Tuno and Takashi Kagaya. 2005. Abundance of mycophagous
arthropods on different fungal species in relation to resource abundance at
different spatial scales. European Journal of Entomology 102: 39-46.
Kazuo
H. Takahashi, Nobuko Tuno and Takashi Kagaya. 2005. The relative importance of
spatial aggregation and resource partitioning on the coexistence of mycophagous
insects. OIKOS 109: 125-134.
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